Stanford images immune signaling complexes
Stanford and SLAC researchers used advanced cryo-ET and cryo-FIB milling to image the NLRP3 inflammasome inside human cells for the first time. The discovery that these complexes form flexible, gel-like condensates rather than rigid structures redefines our understanding of intracellular immune responses.
This breakthrough exposes a long-hidden "black box" of intracellular immunity, proving that textbooks have mischaracterized these signaling complexes for decades. The precision imaging pipeline enables high-resolution 3D reconstruction of molecular assemblies in their native, frozen state. The shift to a "gel-like condensate" model suggests new therapeutic targets focused on the physical properties of protein clusters, while seeing the complex physically push centrioles apart explains why cells stop dividing during an inflammatory response.
DISCOVERED
7d ago
2026-04-04
PUBLISHED
7d ago
2026-04-04
RELEVANCE
AUTHOR
ohjeez